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Fig. 5 | Genome Medicine

Fig. 5

From: Integrated analysis of microbiome and host transcriptome reveals correlations between gut microbiota and clinical outcomes in HBV-related hepatocellular carcinoma

Fig. 5

Associations among liver transcriptome, serum bile acid, and gut microbiota. a Scatter diagrams of OTU abundance (x-axis, square root, and arcsin transformation) and serum bile acids (y-axis). The red horizontal line denotes 12 μmol/L of serum bile acid (n = 52). b Heatmap representing the Pearson correlation coefficients of 100 OTU-gene pairs (upper panel); functional annotation and log2FC of genes related to bile acid metabolism for each patient (lower panel). The red line denotes the average values of log2FC. c Immunohistochemical staining showed that ABCC4 was highly expressed in tumor and adjacent non-tumor liver tissues of patient with high level of bile acid (× 200)

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Genome Medicine

ISSN: 1756-994X

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