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Fig. 5 | Genome Medicine

Fig. 5

From: Genetic feature engineering enables characterisation of shared risk factors in immune-mediated diseases

Fig. 5

Forest plots showing projected values for diseases significant overall and on components 1. Grey square dots indicate projected data and 95% confidence intervals. Red dots indicate the 13 IMD used for basis construction and for which no confidence interval is available. Points to the right of each line indicate disease classification according to whether they have specific autoantibodies that are either directly implicated in disease pathogenesis (“pathogenic”) or which are specific to the disease, but not involved in pathogenesis (“non-pathogenic”). Diseases that are not associated with specific autoantibodies were classified as “none”. ANCA−, anti-neutrophil cytoplasmic antibody negative; Ank. Spond, ankylosing spondylitis; EGPA, eosinophilic granulomatosis with polyangiitis; EO, extended oligo; ERA, juvenile enthesitis-related arthritis; IgGPos, IgG positive; JIA, juvenile idiopathic arthritis; LADA, latent autoimmune diabetes in adults; NMO, neuromyelitis optica; PO, persistent oligo; PsA, psoriatic arthritis; RF+/−, polyarticular rheumatoid factor positive/negative; SLE, systemic lupus erythematosus; UC, ulcerative colitis

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