Fig. 5
From: Genotype imputation and variability in polygenic risk score estimation
Imputation accuracy relative to WGS-based gold standard expressed as R2. a Distribution of R2 values per individual for chromosome 22—average R2 (left) and minimum R2 (right) for 6 replicate imputation runs. Dashed vertical lines indicate the median values. b Range of R2 values achieved per minor allele frequency (MAF) bin for chromosome 22. c Scatterplot of percent variation explained (log-scale) per SNP for CAD PRSs (left: PRSCAD, middle: metaGRSCAD, right: GPSCAD) vs imputation variability as defined by the Gini coefficient of SNP imputation results