From: Genotype imputation and variability in polygenic risk score estimation
Risk tier | Beagle | Eagle+Minimac | SHAPEIT+Minimac |
---|---|---|---|
PRSCAD (161) | |||
 < 5%tile | 1.19% (− 1.13–3.51) | 0% (0–0) | 15.66% (7.84–23.48) |
 < 10%tile | 2.96% (0.4–5.51) | 0% (0–0) | 10.12% (5.56–14.68) |
 < 15%tile | 1.59% (0.04–3.13) | 0% (0–0) | 9.96% (6.26–13.67) |
 < 20%tile | 0.89% (− 0.11–1.9) | 0% (0–0) | 9.91% (6.7–13.12) |
 > 80%tile | 1.78% (0.37–3.19) | 0.3% (− 0.28–0.88) | 10% (6.81–13.19) |
 > 85%tile | 1.98% (0.26–3.69) | 0% (0–0) | 12.7% (8.59–16.81) |
 > 90%tile | 1.19% (− 0.45–2.83) | 0% (0–0) | 17.54% (11.84–23.24) |
 > 95%tile | 4.71% (0.2–9.21) | 0% (0–0) | 15.85% (7.95–23.76) |
 metaGRSCAD (1736608) | |||
 < 5%tile | 6.98% (1.59–12.36) | 1.19% (− 1.13–3.51) | 18.6% (10.38–26.83) |
 < 10%tile | 2.37% (0.07–4.66) | 0% (0–0) | 6.67% (2.86–10.47) |
 < 15%tile | 2.37% (0.5–4.25) | 0.79% (− 0.3–1.88) | 12.94% (8.82–17.06) |
 < 20%tile | 3.82% (1.79–5.86) | 0.3% (− 0.28–0.88) | 8.9% (5.86–11.94) |
 > 80%tile | 2.66% (0.95–4.38) | 0% (0–0) | 9.76% (6.6–12.93) |
 > 85%tile | 4.72% (2.12–7.33) | 0% (0–0) | 12.11% (8.11–16.11) |
 > 90%tile | 6.43% (2.76–10.11) | 0% (0–0) | 6.06% (2.42–9.7) |
 > 95%tile | 2.38% (− 0.88–5.64) | 0% (0–0) | 9.52% (3.25–15.8) |
GPSCAD (6238460) | |||
 < 5%tile | 5.88% (0.88–10.88) | 0% (0–0) | 13.25% (5.96–20.55) |
 < 10%tile | 2.38% (0.08–4.69) | 0.59% (− 0.56–1.75) | 7.78% (3.72–11.85) |
 < 15%tile | 0.79% (− 0.3–1.88) | 0% (0–0) | 9.92% (6.23–13.61) |
 < 20%tile | 1.49% (0.19–2.78) | 0.3% (− 0.28–0.88) | 10% (6.81–13.19) |
 > 80%tile | 2.37% (0.75–3.99) | 0% (0–0) | 8.33% (5.38–11.29) |
 > 85%tile | 1.97% (0.26–3.68) | 0% (0–0) | 6.48% (3.41–9.55) |
 > 90%tile | 2.37% (0.07–4.66) | 0% (0–0) | 5.99% (2.39–9.59) |
 > 95%tile | 1.18% (− 1.12–3.47) | 0% (0–0) | 10.59% (4.05–17.13) |