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Fig. 1 | Genome Medicine

Fig. 1

From: Pervasive generation of non-canonical subgenomic RNAs by SARS-CoV-2

Fig. 1

SARS-CoV-2 generates a defined population of canonical subgenomic RNAs. ac For each location on the viral genome, a histogram of 5′ and 3′ junctions at that position was calculated and plotted as an inverse peak. The histogram bin size is 100 bases, meaning each inverse peak represents the cumulative count of 5′ or 3′ junctions occurring within that span. Curved lines represent the 5′ and 3′ locations of junctions that occur at least twice. Red curves represent canonical junctions, black curves represent non-canonical junctions. “Taiaroa” [7], “Kim” [8], and “Davidson” [9] represent the three independent SARS-CoV-2 dRNAseq datasets investigated. df A histogram of 3′ junctions past position 21000 with a 5′ end before position 100 are plotted. Dashed lines indicate the start coordinates of annotated viral genes. Bin size is 20 bases. g Based on junction analysis, the predicted major species of virus-produced RNAs are represented. The most 5′ gene or genes on each subgenomic RNA is listed

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