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Fig. 3 | Genome Medicine

Fig. 3

From: Pan-cancer identification of clinically relevant genomic subtypes using outcome-weighted integrative clustering

Fig. 3

survClust identifies mutational subtypes associated with survival across cancer types. a Circomap showing total mutation burden (TMB) in brown color and mutational signatures (smoking, MMR, APOBEC, POLE, and aging) in tumors across bladder (BLCA), cervical (CESC), colon (COAD), head and neck (HNSC), liver (LIHC), lung adenocarcinoma (LUAD), lung squamous cell (LUSC), stomach (STAD), and endometrial (UCEC) cancers. Outer circle indicates mutation-based survClust membership. b survClust mutation subtypes in endometrial cancer. From top to bottom: Kaplan-Meier curves for the 4 mutation subtypes; panelmap depicting significantly mutated genes, MSI status, histology, and TMB associated with the subtypes; and beeswarm plot showing CD8 T cell marker expression (y-axis) across the 4 subtypes (x-axis). Red line depicts the median, and top and bottom black bars represent the 25th and 75th percentile, respectively. c survClust mutation subtypes in bladder cancer. From top to bottom: Kaplan-Meier curves for the 3 mutation subtypes; panelmap depicting significantly mutated genes, APOBEC load, and TMB associated with the 3 subtypes; and beeswarm plot showing CD8 T cell expression (y-axis) across the 3 subtypes (x-axis)

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