Fig. 2

Whole blood transcriptomic co-expression modules show extensive correlations with clinical traits in 2127 non-diabetic individuals. a Heatmap showing Pearson’s correlation between modules (rows) and white blood cell estimates. Stars indicate statistical significance as such: ***FDR < 0.001, **FDR < 0.01, *FDR < 0.05. b Heatmap providing overview of the associations between modules and selected clinical traits. The heatmap colors denote the linear regression estimates, where all phenotypes have previously been rank normal transformed and residualized for age, sex, centre and technical covariates. c Boxplots demonstrating the distinct clinical trait associations for the three transcriptomic super-modules, as the average estimate for associations across all modules within a given super-module. P values are shown for Kruskal-Wallis rank sum test between the three super-modules. d T2D associations for each module where the colour indicates a positive (blue) or negative association (red). SM, super-module; IAAT, intra-abdominal adipose tissue