Fig. 2
Manhattan plot showing the APOE ε4 vs. ε2 carrier EWAS and DMR meta-analyses results. Each point represents one of the 772,453 loci included in the EWAS meta-analysis, with the point’s position being determined by genomic position (x-axis) and significance in the EWAS meta-analysis (−log10 P value; y-axis). Sites attaining genome-wide significance (P ≤ 3.6 × 10−8) are indicated in red and those that are involved in a significant DMR (Bonferroni-correct P ≤ 0.05) are indicated in blue. The locations of DMRs are further indicated by vertical blue lines. The solid horizontal line is the threshold for genome-wide significance (P ≤ 3.6 × 10−8)