Identification of epigenome-wide DNA methylation differences between carriers of APOE ε4 and APOE ε2 alleles

Table 2 Significant DMRs identified through DMR meta-analysis of the discovery and replication sample EWAS results

Chr.	Coordinates*	Gene symbol	Effect^†	SE	Adj. P value^‡	CpGs
19	45,449,297–45,449,301	APOC2; APOC4	− 0.231	0.0364	1.63 × 10⁻⁴	cg13119609; cg09555818
19	45,449,099–45,449,150	APOC4-APOC2; APOC2; APOC4	− 0.212	0.0356	0.00203	cg01958934; cg10872931
19	11,199,851–11,199,903	LDLR	− 0.135	0.0245	0.0290	cg07960944; cg05249393; cg22381454;
22	42,230,879–42,230,899	SREBF2	− 0.189	0.0329	0.00755	cg15128785; cg12403973
22	42,229,983–42,230,138	SREBF2	− 0.176	0.0312	0.0118	cg09978077; cg16000331
19	45,429,771–45,429,870	APOC1P1	0.148	0.0269	0.0301	cg23184690; cg08121984

Abbreviations: Chr. chromosome, SE standard error, Adj. adjusted, CpGs cytosine and guanine nucleotides linked by a phosphate bond
*DMR start and end coordinates in genome assembly hg19/GRCh37
^†Effect direction is relative to carriers of the ε2 allele
^‡Bonferroni-adjusted P value

ISSN: 1756-994X