Table 3 Top 20 GO terms showing significant enrichment for APOE ε4 vs. ε2-associated differentially methylated loci

BP

Cholesterol metabolic process

7/146

2.00 × 10⁻¹¹

DHCR24, APOC1, APOE, LDLR, SQLE, SREBF2, ABCG1

BP

Secondary alcohol metabolic process

7/156

3.59 × 10⁻¹¹

DHCR24, APOC1, APOE, LDLR, SQLE, SREBF2, ABCG1

BP

Chylomicron remnant clearance

4/9

4.29 × 10⁻¹¹

APOC1, APOC2, APOE, LDLR

BP

Triglyceride-rich lipoprotein particle clearance

4/9

4.29 × 10⁻¹¹

APOC1, APOC2, APOE, LDLR

BP

Sterol metabolic process

7/162

4.78 × 10⁻¹¹

DHCR24, APOC1, APOE, LDLR, SQLE, SREBF2, ABCG1

BP

Cholesterol homeostasis

6/94

7.57 × 10⁻¹¹

MYLIP, APOC2, APOE, LDLR, SREBF2, ABCG1

BP

Sterol homeostasis

6/94

7.57 × 10⁻¹¹

MYLIP, APOC2, APOE, LDLR, SREBF2, ABCG1

BP

Cholesterol transport

6/98

1.04 × 10⁻¹⁰

APOC1, APOC2, APOE, LDLR, SREBF2, ABCG1

BP

Regulation of plasma lipoprotein particle levels

6/100

1.17 × 10⁻¹⁰

MYLIP, APOC1, APOC2, APOE, LDLR, ABCG1

BP

Phospholipid transport

6/90

1.27 × 10⁻¹⁰

APOC1, APOC2, APOE, KCNN4, LDLR, ABCG1

BP

Regulation of lipid biosynthetic process

7/190

1.50 × 10⁻¹⁰

APOC1, APOC2, APOE, LDLR, SQLE, SREBF2, ABCG1

BP

Phospholipid efflux

4/12

1.50 × 10⁻¹⁰

APOC1, APOC2, APOE, ABCG1

BP

Sterol transport

6/111

2.65 × 10⁻¹⁰

APOC1, APOC2, APOE, LDLR, SREBF2, ABCG1

BP

Cholesterol efflux

5/56

4.60 × 10⁻¹⁰

APOC1, APOC2, APOE, SREBF2, ABCG1

BP

Organophosphate ester transport

6/116

6.18 × 10⁻¹⁰

APOC1, APOC2, APOE, KCNN4, LDLR, ABCG1

BP

Regulation of cholesterol transport

5/61

6.55 × 10⁻¹⁰

APOC1, APOC2, APOE, SREBF2, ABCG1

BP

Regulation of steroid metabolic process

6/123

6.67 × 10⁻¹⁰

APOC1, APOE, LDLR, SQLE, SREBF2, ABCG1

BP

Regulation of sterol transport

5/62

7.34 × 10⁻¹⁰

APOC1, APOC2, APOE, SREBF2, ABCG1

BP

Lipid localization

8/407

7.54 × 10⁻¹⁰

APOC1, APOC2, APOE, KCNN4, LDLR, SQLE, SREBF2, ABCG1

BP

High-density lipoprotein particle remodeling

4/18

1.14 × 10⁻⁹

APOC1, APOC2, APOE, ABCG1