TY - JOUR AU - Kim, Eiru AU - Hart, Traver PY - 2021 DA - 2021/01/06 TI - Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier JO - Genome Medicine SP - 2 VL - 13 IS - 1 AB - Identifying essential genes in genome-wide loss-of-function screens is a critical step in functional genomics and cancer target finding. We previously described the Bayesian Analysis of Gene Essentiality (BAGEL) algorithm for accurate classification of gene essentiality from short hairpin RNA and CRISPR/Cas9 genome-wide genetic screens. SN - 1756-994X UR - https://doi.org/10.1186/s13073-020-00809-3 DO - 10.1186/s13073-020-00809-3 ID - Kim2021 ER -