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Table 1 Overview of main analyses, secondary analyses, and sensitivity analyses

From: DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Analysis

Main analyses

Secondary analyses: binary model (N), cases = overweight and obesity, controls = normal weight

Sensitivity analyses

DNA methylation in the blood

BMI SD scores

N

Europeans only (N)

Without studies > 30% overweight and obesity (N)

Cord blood analyses

 A

Birth (cord blood)

Early childhood (2–5 years)

3295

Cases = 491

Controls = 2540

2902

2989

 B

Birth (cord blood)

Late childhood (5–10 years)

4133

Cases = 707

Controls = 3217

3657

3489

Cross-sectional analyses

 C

Childhood (whole blood)

Childhood (2–10 years)

3371

Cases = 644

Controls = 2567

3026

3171

 D

Adolescence (whole blood)

Adolescence (12–18 years)

2842

Cases = 507

Controls = 2188

NA

NA

  1. Analyses A and B were adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, and estimated cell type proportions
  2. Analyses C was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, estimated cell type proportions, birth weight, and breastfeeding
  3. Analyses D was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, estimated cell type proportions, birth weight, breastfeeding, adolescent sex, age smoking and puberty status
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Genome Medicine

ISSN: 1756-994X

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