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Table 1 Overview of main analyses, secondary analyses, and sensitivity analyses

From: DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Analysis Main analyses Secondary analyses: binary model (N), cases = overweight and obesity, controls = normal weight Sensitivity analyses
DNA methylation in the blood BMI SD scores N Europeans only (N) Without studies > 30% overweight and obesity (N)
Cord blood analyses
 A Birth (cord blood) Early childhood (2–5 years) 3295 Cases = 491
Controls = 2540 		2902 2989
 B Birth (cord blood) Late childhood (5–10 years) 4133 Cases = 707
Controls = 3217 		3657 3489
Cross-sectional analyses
 C Childhood (whole blood) Childhood (2–10 years) 3371 Cases = 644
Controls = 2567 		3026 3171
 D Adolescence (whole blood) Adolescence (12–18 years) 2842 Cases = 507
Controls = 2188 		NA NA
  1. Analyses A and B were adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, and estimated cell type proportions
  2. Analyses C was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, estimated cell type proportions, birth weight, and breastfeeding
  3. Analyses D was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age at birth, batch, estimated cell type proportions, birth weight, breastfeeding, adolescent sex, age smoking and puberty status
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Genome Medicine

ISSN: 1756-994X

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