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Table 2 CpG sites at which DNA methylation was associated with child or adolescent BMI

From: DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

CpG CHR Location Coef SE P value FDR P value Nearest gene
Analysis B = association of cord blood DNA methylation with late childhood BMI (5–10 years)
 cg05937453 10 99531765 0.96288 0.16871 1.15 × 10−8 0.0049 SFRP5
Analysis C = cross-sectional association of whole blood DNA methylation with childhood BMI (2–10 years)
 cg25212453 17 1509953 0.31925 0.05978 9.27 × 10−8 0.02075 SLC43A2
 cg03500056 16 8814507 0.30577 0.05767 1.15 × 10−7 0.02075 ABAT
 cg05281708 3 44690673 0.65856 0.12614 1.78 × 10−7 0.02075 ZNF35
 cg15125798 5 122621645 0.49705 0.09548 1.93 × 10−7 0.02075
 cg04456029 12 113496126 0.27587 0.05358 2.63 × 10−7 0.0226 DTX1
 cg03431111 11 62621406 0.19261 0.03791 3.77 × 10−7 0.0270 SNORD30; SNORD22; SNORD29; SNORD31; SNHG1
 cg26889953 15 22915992 0.31743 0.06391 6.81 × 10−7 0.0304 CYFIP1
 cg19743522 12 113495566 0.33854 0.0682 6.92 × 10−7 0.0304 DTX1
 cg25877069 8 95003236 − 0.45126 0.09092 6.94 × 10−7 0.0304
 cg13931559 20 33146515 − 0.84718 0.17082 7.07 × 10−7 0.0304 MAP1LC3A
Analysis D = cross-sectional association of whole blood DNA methylation with adolescent BMI (12–18 years)
 cg10040131 2 73178866 0.32434 0.0566 1.00 × 10−8 0.0043 SFXN5
  1. Coefficients (Coef) and standard errors (SE) are presented per 10% increase in the methylation level
  2. Analyses B was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age, batch, and estimated cell type proportions. Analysis C was additionally adjusted for child covariates birth weight and breastfeeding, whereas analysis D was adjusted for the same covariates as analysis C plus adolescent sex, age, smoking, and puberty status
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