DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

Vehmeijer, Florianne O. L.; Küpers, Leanne K.; Sharp, Gemma C.; Salas, Lucas A.; Lent, Samantha; Jima, Dereje D.; Tindula, Gwen; Reese, Sarah; Qi, Cancan; Gruzieva, Olena; Page, Christian; Rezwan, Faisal I.; Melton, Philip E.; Nohr, Ellen; Escaramís, Geòrgia; Rzehak, Peter; Heiskala, Anni; Gong, Tong; Tuominen, Samuli T.; Gao, Lu; Ross, Jason P.; Starling, Anne P.; Holloway, John W.; Yousefi, Paul; Aasvang, Gunn Marit; Beilin, Lawrence J.; Bergström, Anna; Binder, Elisabeth; Chatzi, Leda; Corpeleijn, Eva; Czamara, Darina; Eskenazi, Brenda; Ewart, Susan; Ferre, Natalia; Grote, Veit; Gruszfeld, Dariusz; Håberg, Siri E.; Hoyo, Cathrine; Huen, Karen; Karlsson, Robert; Kull, Inger; Langhendries, Jean-Paul; Lepeule, Johanna; Magnus, Maria C.; Maguire, Rachel L.; Molloy, Peter L.; Monnereau, Claire; Mori, Trevor A.; Oken, Emily; Räikkönen, Katri; Rifas-Shiman, Sheryl; Ruiz-Arenas, Carlos; Sebert, Sylvain; Ullemar, Vilhelmina; Verduci, Elvira; Vonk, Judith M.; Xu, Cheng-jian; Yang, Ivana V.; Zhang, Hongmei; Zhang, Weiming; Karmaus, Wilfried; Dabelea, Dana; Muhlhausler, Beverly S.; Breton, Carrie V.; Lahti, Jari; Almqvist, Catarina; Jarvelin, Marjo-Riitta; Koletzko, Berthold; Vrijheid, Martine; Sørensen, Thorkild I. A.; Huang, Rae-Chi; Arshad, Syed Hasan; Nystad, Wenche; Melén, Erik; Koppelman, Gerard H.; London, Stephanie J.; Holland, Nina; Bustamante, Mariona; Murphy, Susan K.; Hivert, Marie-France; Baccarelli, Andrea; Relton, Caroline L.; Snieder, Harold; Jaddoe, Vincent W. V.; Felix, Janine F.

doi:10.1186/s13073-020-00810-w

Table 2 CpG sites at which DNA methylation was associated with child or adolescent BMI

From: DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studies

CpG	CHR	Location	Coef	SE	P value	FDR P value	Nearest gene
Analysis B = association of cord blood DNA methylation with late childhood BMI (5–10 years)
cg05937453	10	99531765	0.96288	0.16871	1.15 × 10⁻⁸	0.0049	SFRP5
Analysis C = cross-sectional association of whole blood DNA methylation with childhood BMI (2–10 years)
cg25212453	17	1509953	0.31925	0.05978	9.27 × 10⁻⁸	0.02075	SLC43A2
cg03500056	16	8814507	0.30577	0.05767	1.15 × 10⁻⁷	0.02075	ABAT
cg05281708	3	44690673	0.65856	0.12614	1.78 × 10⁻⁷	0.02075	ZNF35
cg15125798	5	122621645	0.49705	0.09548	1.93 × 10⁻⁷	0.02075	–
cg04456029	12	113496126	0.27587	0.05358	2.63 × 10⁻⁷	0.0226	DTX1
cg03431111	11	62621406	0.19261	0.03791	3.77 × 10⁻⁷	0.0270	SNORD30; SNORD22; SNORD29; SNORD31; SNHG1
cg26889953	15	22915992	0.31743	0.06391	6.81 × 10⁻⁷	0.0304	CYFIP1
cg19743522	12	113495566	0.33854	0.0682	6.92 × 10⁻⁷	0.0304	DTX1
cg25877069	8	95003236	− 0.45126	0.09092	6.94 × 10⁻⁷	0.0304	–
cg13931559	20	33146515	− 0.84718	0.17082	7.07 × 10⁻⁷	0.0304	MAP1LC3A
Analysis D = cross-sectional association of whole blood DNA methylation with adolescent BMI (12–18 years)
cg10040131	2	73178866	0.32434	0.0566	1.00 × 10⁻⁸	0.0043	SFXN5

Coefficients (Coef) and standard errors (SE) are presented per 10% increase in the methylation level
Analyses B was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age, batch, and estimated cell type proportions. Analysis C was additionally adjusted for child covariates birth weight and breastfeeding, whereas analysis D was adjusted for the same covariates as analysis C plus adolescent sex, age, smoking, and puberty status

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