|
CpG
|
CHR
|
Location
|
Coef
|
SE
|
P value
|
FDR P value
|
Nearest gene
|
|---|
|
Analysis B = association of cord blood DNA methylation with late childhood BMI (5–10 years)
|
|
cg05937453
|
10
|
99531765
|
0.96288
|
0.16871
|
1.15 × 10−8
|
0.0049
|
SFRP5
|
|
Analysis C = cross-sectional association of whole blood DNA methylation with childhood BMI (2–10 years)
|
|
cg25212453
|
17
|
1509953
|
0.31925
|
0.05978
|
9.27 × 10−8
|
0.02075
|
SLC43A2
|
|
cg03500056
|
16
|
8814507
|
0.30577
|
0.05767
|
1.15 × 10−7
|
0.02075
|
ABAT
|
|
cg05281708
|
3
|
44690673
|
0.65856
|
0.12614
|
1.78 × 10−7
|
0.02075
|
ZNF35
|
|
cg15125798
|
5
|
122621645
|
0.49705
|
0.09548
|
1.93 × 10−7
|
0.02075
|
–
|
|
cg04456029
|
12
|
113496126
|
0.27587
|
0.05358
|
2.63 × 10−7
|
0.0226
|
DTX1
|
|
cg03431111
|
11
|
62621406
|
0.19261
|
0.03791
|
3.77 × 10−7
|
0.0270
|
SNORD30; SNORD22; SNORD29; SNORD31; SNHG1
|
|
cg26889953
|
15
|
22915992
|
0.31743
|
0.06391
|
6.81 × 10−7
|
0.0304
|
CYFIP1
|
|
cg19743522
|
12
|
113495566
|
0.33854
|
0.0682
|
6.92 × 10−7
|
0.0304
|
DTX1
|
|
cg25877069
|
8
|
95003236
|
− 0.45126
|
0.09092
|
6.94 × 10−7
|
0.0304
|
–
|
|
cg13931559
|
20
|
33146515
|
− 0.84718
|
0.17082
|
7.07 × 10−7
|
0.0304
|
MAP1LC3A
|
|
Analysis D = cross-sectional association of whole blood DNA methylation with adolescent BMI (12–18 years)
|
|
cg10040131
|
2
|
73178866
|
0.32434
|
0.0566
|
1.00 × 10−8
|
0.0043
|
SFXN5
|
- Coefficients (Coef) and standard errors (SE) are presented per 10% increase in the methylation level
- Analyses B was adjusted for maternal age, educational level, smoking status, pre-pregnancy or early pregnancy BMI, parity, gestational age, batch, and estimated cell type proportions. Analysis C was additionally adjusted for child covariates birth weight and breastfeeding, whereas analysis D was adjusted for the same covariates as analysis C plus adolescent sex, age, smoking, and puberty status
