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Fig. 2 | Genome Medicine

Fig. 2

From: Transcriptome-wide profiles of circular RNA and RNA-binding protein interactions reveal effects on circular RNA biogenesis and cancer pathway expression

Fig. 2

KHSRP binding is enriched in introns flanking circRNAs and affects biogenesis. a Illustration of circRNA and exon categories and intronic location of KHSRP binding sites. The categories are defined as the top 1% highest expressed circRNAs (green), all other circRNAs (orange), and non-circularizing exons from genes producing circRNAs (purple). First and last exons in each gene are disregarded for the analyses. b Percentage of circRNAs and non-circ-exons in genes producing circRNAs with KHSRP binding sites in both flanking introns in K562. P values obtained by chi-square test. c Percentage of circRNAs and non-circ-exons in genes producing circRNAs with inverted repeated Alu elements (IRAlus) in both flanking introns in K562. P values obtained by chi-square test. d Total expression of circRNAs with (left, n = 297) and without (right, n = 1537) KHSRP binding sites in both flanking introns in KHSRP knockdown (KD) and control samples in K562. P values obtained by T-test. RPM = reads per million. e Expression of circRNAs with KHSRP binding sites and with (left, n = 95) or without (right, n = 202) IRAlus in both flanking introns in KHSRP knockdown (KD) and control samples in K562. P values obtained by T-test

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