Fig. 1
From: Genetic variation in the Middle East—an opportunity to advance the human genetics field
Genomic data representation. Top, Distribution of sample ancestries in the GWAS Catalog as of June 14, 2020 [5]. Middle, Distribution of sample ancestries in the Genome Aggregation Database (gnomAD v2.1) [1] and the Greater Middle East (GME) variome [6] studies. Bottom, Human knockouts (KOs) or the number of genes with homozygous loss of function (LoF) variant(s) in exomes from individuals of the Greater Middle East [6], Pakistan [7], and gnomAD v2.1 [1]. Circle size correlates with a fraction of the number of KOs in a given sample size. F = coefficient of inbreeding