Skip to main content
Fig. 4 | Genome Medicine

Fig. 4

From: Disease severity-specific neutrophil signatures in blood transcriptomes stratify COVID-19 patients

Fig. 4

Integration with signatures from other diseases reveals COVID-19-specific characteristics. a Schema of analysis of the integrated dataset. The integrated dataset was analyzed with regard to expression patterns of the clusters previously identified in the whole blood COVID-19-specific co-expression network. b Heat map of mean group fold changes of CoCena2 module comparison between COVID-19 and other diseases. From left to right, the diseases are ordered by category (COVID-19, viral infections, bacterial infections, and others). On the right side of the heat map, the first box plot shows the enriched immune cell markers in each module. The second box plot shows the enrichment of genes upregulated in specific neutrophil subtypes based on cross-referencing with single-cell data [34]. Both box plots show enriched cell types in percent of total hits; absolute hits with respect to cluster size are stated aside. c Gene set variation analysis was conducted for every single patient based on Hallmark gene sets as shown in Fig. 2d. The result was standardized to retrieve the z-scores; a disease mean was calculated and displayed as a dot plot with size and color correlating to the z-score. The labels on the x-axis are the same as in b

Back to article page