Table 3 Immunization with highly reactive Shigella proteins elicits protective antibody responses. Rabbits were immunized with 0.2 mg of Shigella proteins, and sera (at 1 week post-immunization) were tested in vitro for serum bactericidal activity (SBA) against Shigella flexneri, Shigella sonnei, and Shigella Typhimurium. SBA titers presented below are estimated at 50% bactericidal activity
From: The identification of novel immunogenic antigens as potential Shigella vaccine components
| Post-immunization SBA titer (μg/ml) | SBA titer (dilution) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| fepA | nmpC | cjrA | emrK | fhuA | htrB | mdtA | nlpB | Shigella-immune sera | |
| Shigella flexneri | 0.4 | > 50 | 0.0046 | 0.7 | 4.8 | > 50 | 10.2 | 0.92 | 44,321 |
| Shigella sonnei | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | 29,561 |
| Salmonella Typhimurium | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 | > 50 |