TY - JOUR AU - Dayama, Gargi AU - Priya, Sambhawa AU - Niccum, David E. AU - Khoruts, Alexander AU - Blekhman, Ran PY - 2020 DA - 2020/01/28 TI - Interactions between the gut microbiome and host gene regulation in cystic fibrosis JO - Genome Medicine SP - 12 VL - 12 IS - 1 AB - Cystic fibrosis is the most common autosomal recessive genetic disease in Caucasians. It is caused by mutations in the CFTR gene, leading to poor hydration of mucus and impairment of the respiratory, digestive, and reproductive organ functions. Advancements in medical care have led to markedly increased longevity of patients with cystic fibrosis, but new complications have emerged, such as early onset of colorectal cancer. Although the pathogenesis of colorectal cancer in cystic fibrosis remains unclear, altered host-microbe interactions might play a critical role. To investigate this, we characterized changes in the microbiome and host gene expression in the colonic mucosa of cystic fibrosis patients relative to healthy controls, and identified host gene-microbiome interactions in the colon of cystic fibrosis patients. SN - 1756-994X UR - https://doi.org/10.1186/s13073-020-0710-2 DO - 10.1186/s13073-020-0710-2 ID - Dayama2020 ER -