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Fig. 3 | Genome Medicine

Fig. 3

From: A proactive genotype-to-patient-phenotype map for cystathionine beta-synthase

Fig. 3

Variant effect maps confirm that vitamin B6 is more likely to remediate the weakest effect variants. a Distributions of low vitamin B6 fitness scores for variants that were deleterious under the low vitamin B6 condition, separated according to whether or not they were vitamin B6 remediable. b Plasma CBS activity distributions of vitamin B6-responsive and non-responsive homocystinuria patients (relative to median activity in controls)

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