TY - JOUR AU - Espeso-Gil, Sergio AU - Halene, Tobias AU - Bendl, Jaroslav AU - Kassim, Bibi AU - Ben Hutta, Gabriella AU - Iskhakova, Marina AU - Shokrian, Neda AU - Auluck, Pavan AU - Javidfar, Behnam AU - Rajarajan, Prashanth AU - Chandrasekaran, Sandhya AU - Peter, Cyril J. AU - Cote, Alanna AU - Birnbaum, Rebecca AU - Liao, Will AU - Borrman, Tyler AU - Wiseman, Jennifer AU - Bell, Aaron AU - Bannon, Michael J. AU - Roussos, Panagiotis AU - Crary, John F. AU - Weng, Zhiping AU - Marenco, Stefano AU - Lipska, Barbara AU - Tsankova, Nadejda M. AU - Huckins, Laura AU - Jiang, Yan AU - Akbarian, Schahram PY - 2020 DA - 2020/02/19 TI - A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons JO - Genome Medicine SP - 19 VL - 12 IS - 1 AB - Midbrain dopaminergic neurons (MDN) represent 0.0005% of the brain’s neuronal population and mediate cognition, food intake, and metabolism. MDN are also posited to underlay the neurobiological dysfunction of schizophrenia (SCZ), a severe neuropsychiatric disorder that is characterized by psychosis as well as multifactorial medical co-morbidities, including metabolic disease, contributing to markedly increased morbidity and mortality. Paradoxically, however, the genetic risk sequences of psychosis and traits associated with metabolic disease, such as body mass, show very limited overlap. SN - 1756-994X UR - https://doi.org/10.1186/s13073-020-0715-x DO - 10.1186/s13073-020-0715-x ID - Espeso-Gil2020 ER -