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Fig. 2 | Genome Medicine

Fig. 2

From: A chromosomal connectome for psychiatric and metabolic risk variants in adult dopaminergic neurons

Fig. 2

Schizophrenia and body mass index risk architectures mapped onto the spatial genome of midbrain dopaminergic neurons. a Nurr1+/NeuN+ Tn5HiC library (761M reads) chrom3D in silico modeling. Shared domains (red beads) harbor both BMI and SCZ risk variants. b Interaction matrices at 25 kb resolution, showing sharp boundaries between domains including their nested subdomains. c (top to bottom) BMI and SCZ summary bar plots, including as indicated, N SNPs/loci in the domains in addition to proportion of SCZ, BMI, and shared (SCZ + BMI) domains in the spatial genome model with approximately 3000 domains. d Euclidean pairwise distances between 100 domains with shared BMI and SCZ risk variants, defining 11 Euclidean hot spots (EHs) of domains that are spatially close together. δ is defined as pairwise distances of BMI + SCZ risk domains measured in Euclidean geometrical units. e GO analysis and selected terms of SNP-associated genes in the EHs (N = 339 total genes, p value< 0.05, Bonferroni adjusted). f EH gene-associated BMI-SCZ risk contacts, with String-db proteome interactome [75] of high confidence interactions (0.9), colors represent gene ontology as in Fig. 2f. g Significant selected GO analysis terms (p value< 0.05, Bonferroni adjusted) of transcription factors binding to non-coding regulatory elements (TNE) regions found to anchored at EH risk interactions (333 total TNEs found harboring 251 motifs). h EH transcription factor interactome [75] bound to TNE regions in EH risk interactions at high confidence level (0.95), colors represent the transcription factors found in the gene ontology analysis (left)

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