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Table 1 Summary of clinical information of all cases harboring 13q12.2 focal amplification

From: Cell-free DNA analysis reveals POLR1D-mediated resistance to bevacizumab in colorectal cancer

Patient ID

Disease stage (TC)

Disease stage (PC)

Location

cM (TC)

cM (PC)

TBC (months)

Detection*

C74

IV B

IV B

Rectum

M1

M1

22.8

Yes

C79

NA

NA

NA

NA

NA

NA

No

C95

II A

IV B

Left flexure

M0

M1

43.4

NA

C109

III B

IV B

Rectum

M0

M1

101.7

Yes

C110

IV A

IV B

Colon ascending

M1

M1

0.7

NA

C118

IV B

IV B

Colon sigmoid

M0

M1

22.9

No

C112

III A

IV B

Rectum

NA

NA

27.1

NA

C123

III B

IV B

Colon sigmoid

M0

M1

76.5

Yes

C129

I

IV B

Colon sigmoid

M0

M1

121.3

NA

C166

IV A

IV A

Colon transverse

M1

M1

0.7

No

C178

III C

IV B

Cecum

M0

M1

5.4

Yes

C206

III B

III B

Rectum

M0

M0

7.6

No

C240

III B

IV B

Colon sigmoid

M0

M1

79.9

No

C216+

NA

IV B

NA

NA

NA

NA

NA

  1. The age range of the 14 patients was 45–81 years (mean = 60.7 years, median = 51 years), 36% were female, and 64% were male. TC tissue collection, PC plasma collection, TBC time to first blood collection after diagnosis
  2. *13q12.2 SCNA found in primary tissue; +13q12.2 SCNA was not detected in the first blood draw in patient C216