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Fig. 2 | Genome Medicine

Fig. 2

From: Large-scale public data reuse to model immunotherapy response and resistance

Fig. 2

Prioritization of genes with approved drugs. A total of 696 genes with launched drugs were collected from the OASIS database [9] (Additional file 5: Table S4). Among the gene set, top 20 hits were presented. Genes (row) are ranked by their weighted average value across four immunosuppressive indices (columns), including T cell dysfunction score, T cell exclusion score, association with ICB survival outcome, and log-fold change (logFC) in CRISPR screens. The T dysfunction score shows how a gene interacts with cytotoxic T cells to influence patient survival outcome, and the T cell exclusion score assesses the gene expression levels in immunosuppressive cell types that drive T cell exclusion. The association score of (z-score in the Cox-PH regression) ICB survival outcome evaluates genes whose activities are correlated with ICB benefit. The normalized logFC in CRISPR screens help identify regulators whose knockout can mediate the efficacy of lymphocyte-mediated tumor killing in cancer models

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