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Table 2 Overview of blood and skin SMR analyses detailing tissue-specific and common BCC susceptibility genes

From: Genetic and functional interaction network analysis reveals global enrichment of regulatory T cell genes influencing basal cell carcinoma susceptibility

Tissue Number of SMR genes Sample size Number of probes tested P value threshold of multiple correction
 Blood (eQTLGen) 46 31,684 15,652 3.19E−06
 Skin_Sun_Exposed (GTEx) 25 243 6557 7.63E−06
 Skin_Not_Sun_Exposed (GTEx) 21 216 5252 9.52E−06
 Whole_Blood (GTEx) 20 360 4459 1.12E−05
 Overall number of unique elements 63 / / /
Tissue Number of overlapping genes Gene name
 Blood (eQTLGen)
 Skin_Not_Sun_Exposed (GTEx)
 Skin_Sun_Exposed (GTEx)
 Whole_Blood (GTEx)
7 SPIRE2, CDK10, HLA-DRB1, HLA-DQA2, AL133458.1, RNASET2, CASP8
 Blood (eQTLGen)
 Skin_Not_Sun_Exposed (GTEx)
 Skin_Sun_Exposed (GTEx)
1 ALS2CR12
 Blood (eQTLGen)
 Skin_Sun_Exposed (GTEx)
 Whole_Blood (GTEx)
1 SPATA2L
 Skin_Not_Sun_Exposed (GTEx)
 Skin_Sun_Exposed (GTEx)
 Whole_Blood (GTEx)
2 HLA-DOB, HLA-DRB6
 Blood (eQTLGen)
 Skin_Sun_Exposed (GTEx)
3 CLPTM1L, RP11-104N10.1, ALKBH5
 Blood (eQTLGen)
 Skin_Not_Sun_Exposed (GTEx)
3 SMC2, TGM3, NCOA6
 Blood (eQTLGen)
 Whole_Blood (GTEx)
7 RCC2, SPG7, PADI6, SPATA33, MAP1LC3A, CDKN2B, AP003774.1
 Skin_Not_Sun_Exposed (GTEx)
 Skin_Sun_Exposed (GTEx)
7 DBNDD1, TCF19, ASIP, PSORS1C3, HLA-DQA1, KRT6C, POU5F1
Tissue Number of unique genes Gene name
 Blood (eQTLGen) 24 VDR, RP1-167A14.2, GGT7, IRF4, EIF2S2, TAP2, TRPC4AP, BNC2, AC007256.5, RP11-875O11.1, GAS8, RPS6KA2, ZNF276, CCR6, PES1, BACH2, CASP10, TP53, TP53INP2, CTLA4, AC137932.6, CHMP4B, STRADB, TICAM1
 Skin_Sun_Exposed (GTEx) 4 FANCA, SEMA6C, CTSS, URAHP
 Skin_Not_Sun_Exposed (GTEx) 1 FGFR1OP
 Whole_Blood (GTEx) 3 CHMP1A, HLA-DRB9, SPAG1
  1. Table revealing the number of SMR genes, sample size, number of probes tested, and multiple correction threshold in each tissue and the SMR genes unique to each tissue-gene dataset and list of SMR genes common among datasets. In the eQTLGen dataset, the gene name SPATA33 is aliased as C16orf55. To ease gene comparison analyses, C16orf55 was changed to SPATA33 in the eQTLGen results