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Table 3 Feature weights resulting from multivariate logistic regression

From: Highly elevated polygenic risk scores are better predictors of myocardial infarction risk early in life than later

Feature

Weight (IHD Score)

Weight (MI Score)

Weight (early MI Score)

FDR202

0.09 ± 0.01

0.14 ± 0.00

0.24 ± 0.01

GRS46K

0.16 ± 0.00

0.23 ± 0.00

0.24 ± 0.02

1.7M

0.12 ± 0.00

0.17 ± 0.00

0.44 ± 0.01

6M

1.83 ± 0.02

1.85 ± 0.02

0.23 ± 0.01

Diabetes type 2

1.00 ± 0.01

0.80 ± 0.01

1.10 ± 0.05

Family History of Heart Disease

1.01 ± 0.00

0.98 ± 0.01

1.54 ± 0.04

Sex

0.65 ± 0.00

1.02 ± 0.01

1.46 ± 0.04

Birth year

− 0.78 ± 0.00

− 0.79 ± 0.00

1.22 ± 0.02

Systolic blood pressure

− 0.03 ± 0.00

− 0.07 ± 0.00

− 0.37 ± 0.01

BMI

0.23 ± 0.00

0.19 ± 0.00

0.36 ± 0.02

Cholesterol

− 0.34 ± 0.01

− 0.39 ± 0.00

− 0.84 ± 0.02

Triglycerides

0.18 ± 0.00

0.19 ± 0.00

0.32 ± 0.01

LDL

0.17 ± 0.01

0.27 ± 0.02

− 0.77 ± 0.07

Smoking status

0.34 ± 0.00

0.45 ± 0.00

0.57 ± 0.02

PC1

0.17 ± 0.00

0.05 ± 0.04

− 0.09 ± 0.48

PC2

0.16 ± 0.02

0.16 ± 0.04

− 0.39 ± 0.30

PC3

0.01 ± 0.00

0.02 ± 0.00

0.05 ± 0.01

PC4

0.00 ± 0.00

0.01 ± 0.00

0.02 ± 0.01

  1. Feature weights from training the 14-feature logistic regression algorithm, with 95% confidence intervals from 10-fold cross-validation