From: Pan-cancer detection of driver genes at the single-patient resolution
Category | Property | Feature | Type |
---|---|---|---|
Molecular | Gene mutation | Mutational load (n) | Continuous |
Non-truncating damaging mutations (n) | Continuous | ||
Truncating mutations (n) | Continuous | ||
Hotspot mutations (n) | Continuous | ||
Gene copy number | Gene copy number (n) | Continuous | |
Gene is amplified | Binary | ||
Gene is deleted | Binary | ||
Systems-level | Gene duplication | Gene is duplicated | Binary |
Gene is an ohnolog | Binary | ||
Gene essentiality | Cell lines in which gene is essential (%) | Continuous | |
Gene is essential | Binary | ||
Gene expression | Tissues expressing gene (n) | Continuous | |
Gene is expressed in 0 tissues | Binary | ||
Gene is expressed in 7 ≤ tissues ≤ 36 | Binary | ||
Protein expression | Tissues expressing protein (n) | Continuous | |
Protein is expressed in ≥ 41 tissues | Binary | ||
Protein-protein interaction network (PPIN) | PPIN degree | Continuous | |
Protein is a PPIN hub | Binary | ||
PPIN betweenness | Continuous | ||
PPIN clustering coefficient | Continuous | ||
Protein complexes | Complexes the protein is part of (n) | Continuous | |
miRNA interactions | miRNAs targeting the gene (n) | Continuous | |
Gene evolutionary origin | Pre-metazoan origin | Binary | |
Metazoan origin | Binary | ||
Vertebrate origin | Binary | ||
Post-vertebrate origin | Binary |