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Fig. 2 | Genome Medicine

Fig. 2

From: Development of genome-wide polygenic risk scores for lipid traits and clinical applications for dyslipidemia, subclinical atherosclerosis, and diabetes cardiovascular complications among East Asians

Fig. 2

Odds ratio (OR) of coronary heart disease stratified by quintile of polygenic risk scores [a PRSTC, b PRSTG, c PRSHDL, and d PRSLDL] in T2D patients (n = 2374 cases vs 6246 controls). Plinear refers to the p value testing for a linear trend across five quintiles of polygenic risk score. Ptop refers to the p value testing for the association of a high polygenic risk score with coronary heart disease by comparing the top 20% of the distribution with the remaining 80% of the distribution. Pbottom refers to the p value testing for the association of a low polygenic risk score with coronary heart disease by comparing the bottom 20% of the distribution with the remaining 80% of the distribution. Within each individual cohort, all p values were obtained from logistic regression with the adjustment of principal components, sex, age, duration of diabetes, body mass index, smoking status, HbA1c, systolic blood pressure, estimated glomerular filtration rate, and log-transformed albumin-creatinine ratio. Results from individual cohorts were meta-analyzed using fixed effects model

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