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Fig. 2 | Genome Medicine

Fig. 2

From: Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Fig. 2

Effects of altered epigenetic modifiers. DNA methylation levels are maintained by a balance between methylation and demethylation. Mutations inactivating DNA methyltransferases (DNMT), such as DNMT3A, lead to hypomethylation and thereby affect gene transcription what might influence processes involved in tumorigenesis for example differentiation. Ten-eleven translocator (TET) enzymes demethylate DNA but can be inhibited by 2-hydroxyglutarate produced by mutated isocitrate-dehydrogenases. DNA hypermethylation is associated with gene silencing

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Genome Medicine

ISSN: 1756-994X

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