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Fig. 3 | Genome Medicine

Fig. 3

From: Epigenetic signatures in cancer: proper controls, current challenges and the potential for clinical translation

Fig. 3

Impact of oncohistone mutations on modifications of the H3 and H3.3 N-terminal tail. a The N-terminal tail of H3 and H3.3 can be modified at several positions with different marks influencing the epigenetic state. K9me3 and K27me3 are associated with a heterochromatic state whereas K4me3, K36me3, and K27ac are found in active chromatin. b Some modification hot spots of H3 and H3.3 are found to be mutated in several cancer entities. They disrupt the epigenome by inhibition of epigenetic writers such as NSD2 or EZH2. The mechanism of H3.3 G34 mutation-associated disruption of the epigenome is currently intensely studied

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Genome Medicine

ISSN: 1756-994X

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