Fig. 2
From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score
gSOS is more strongly associated with fracture risk than most clinical risk factors. a Comparison of associations between incident major osteoporotic fracture risk and risk factors. Different thresholds of gSOS were selected such that a similar proportion of the population would be affected by one of the clinical risk factors. b Comparison of the predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident major osteoporotic fracture. c Comparison of associations between incident hip fracture risk and risk factors. d Comparison of the predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident hip fracture. Comparison of each clinical risk factor AUROC to gSOS AUROC was based on DeLong’s test; p values are presented in b and d. All association tests were based on logistic regression models, adjusted for age and sex in individuals from four European ancestry cohorts. Only clinical risk factors available in all cohorts are presented in b and d, based on 12,359 individuals with complete data. 95% CIs of AUROC were derived from 200 bootstrap replicates. Summaries of the cohort-specific predictive performance of all risk factors are provided in Additional file 1: Table S4