Fig. 3
From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score
gSOS effectively stratifies cumulative fracture risk. a Lower gSOS is associated with a higher cumulative incidence of major osteoporotic fracture. b Comparison of the age-dependent predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident major osteoporotic fracture. c Lower gSOS is associated with a higher cumulative incidence of hip fracture. d Comparison of the age-dependent predictive performance of gSOS (red) and clinical risk factors (blue) in identifying individuals that experienced incident hip fracture. All association tests were based on 4663 men from the MrOS US and 3615 women from the SOF cohorts using Cox proportional hazard models adjusted for sex. Only clinical risk factors available in both cohorts are presented. CIs of C-index were derived from 200 bootstrap replicates