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Table 1 Study characteristics

From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Characteristic UK Biobank test dataset MrOS US MrOS Sweden SOF CKB
Mean/N Missing/N Mean/N Missing/N Mean/N Missing/N Mean/N Missing/N Mean/N Missing/N
Sample size 80,014   4663   1880   3615   25,034  
Baseline age (SD) 56.8 (8.0)   74.0 (6.0)   75.4 (3.2)   71.5 (5.3)   53.7 (11.0)  
Women (%) 43,723 (54.6)   0   0   3615 (100)   14,334 (57.3)  
Baseline BMI (SD) 27.3 (4.7) 4 27.4 (3.8) 1 26.4 (3.5)   26.7 (4.6)   23.7 (3.5)  
Prior fracture (%) 8008 (10.0) 21 1087 (23.3) 4 637 (33.9) 1 1274 (35.4) 17 2290 (9.2)  
Smoking (%) 6908 (8.6)   146 (3.1) 1 178 (9.5) 6 285 (7.9) 13 7957 (31.8)  
Corticosteroids use (%) 923 (1.2)   98 (2.2) 164 34 (1.8) 6 387 (10.9) 62   25,034
Rheumatoid arthritis (%) 758 (1.0)   226 (4.8)   27 (1.5) 23 252 (7.1) 74 572 (2.3)  
Parental fracture (%)   80,014 600 (16.8) 1098 164 (13.7) 686 424 (14.3) 646   25,034
At-risk drinking* (%)   80,014 182 (3.9) 6 52 (2.8) 27 102 (2.8) 1   25,034
Baseline falls§ (%)   80,014 984 (21.1)   298 (15.9) 6 1021 (28.3) 6   25,034
Secondary osteoporosis (%) 3352 (4.2)    4663   1880   3615   25,034
FRAX for MOF (SD) 5.1 (3.1)   9.5 (4.7) 1 13.1 (5.6)   18.7 (9.5)    
FRAX for hip fracture (SD) 0.7 (0.9)   3.8 (3.8) 1 7.0 (4.9)   6.4 (7.0)    
FRAX-gSOS for MOF (SD) 5.4 (3.9)   10.1 (6.0) 6 13.7 (7.3)   19.3 (11.2) 38   
FRAX-gSOS for hip fracture (SD) 0.9 (1.2)   4.2 (4.8) 6 7.7 (6.5)   7.0 (8.1) 38   
FRAX-BMD for MOF (SD) 4.9 (2.6) 75,273 8.1 (4.4) 2 11.1 (6.3) 19 17.1 (9.5) 151   
FRAX-BMD for hip fracture (SD) 0.7 (1.0) 75,273 2.5 (3.3) 2 5.3 (5.5) 19 5.0 (6.7) 151   
Incident major osteoporotic fracture (incidence proportion) 1189 (1.5)   560 (12.0)   337 (17.9)   707 (20.6)   323 (1.3)  
Incident hip fracture (incidence proportion) 209 (0.3)   273 (5.9)   129 (6.9)   556 (15.6)   67 (0.3)  
  1. *Though alcohol use is available in the UK Biobank and the CKB, no information regarding the frequency of drinking to determine at-risk drinking (≥ 3 drinks per day)
  2. §The UK Biobank only records self-reported falls in the past 12 months at the baseline visit