Table 1 Study characteristics

Sample size

80,014

4663

1880

3615

25,034

Baseline age (SD)

56.8 (8.0)

74.0 (6.0)

75.4 (3.2)

71.5 (5.3)

53.7 (11.0)

Women (%)

43,723 (54.6)

0

0

3615 (100)

14,334 (57.3)

Baseline BMI (SD)

27.3 (4.7)

4

27.4 (3.8)

1

26.4 (3.5)

26.7 (4.6)

23.7 (3.5)

Prior fracture (%)

8008 (10.0)

21

1087 (23.3)

4

637 (33.9)

1

1274 (35.4)

17

2290 (9.2)

Smoking (%)

6908 (8.6)

146 (3.1)

1

178 (9.5)

6

285 (7.9)

13

7957 (31.8)

Corticosteroids use (%)

923 (1.2)

98 (2.2)

164

34 (1.8)

6

387 (10.9)

62

25,034

Rheumatoid arthritis (%)

758 (1.0)

226 (4.8)

27 (1.5)

23

252 (7.1)

74

572 (2.3)

Parental fracture (%)

80,014

600 (16.8)

1098

164 (13.7)

686

424 (14.3)

646

25,034

At-risk drinking* (%)

80,014

182 (3.9)

6

52 (2.8)

27

102 (2.8)

1

25,034

Baseline falls^§ (%)

80,014

984 (21.1)

298 (15.9)

6

1021 (28.3)

6

25,034

Secondary osteoporosis (%)

3352 (4.2)

4663

1880

3615

25,034

FRAX for MOF (SD)

5.1 (3.1)

9.5 (4.7)

1

13.1 (5.6)

18.7 (9.5)

FRAX for hip fracture (SD)

0.7 (0.9)

3.8 (3.8)

1

7.0 (4.9)

6.4 (7.0)

FRAX-gSOS for MOF (SD)

5.4 (3.9)

10.1 (6.0)

6

13.7 (7.3)

19.3 (11.2)

38

FRAX-gSOS for hip fracture (SD)

0.9 (1.2)

4.2 (4.8)

6

7.7 (6.5)

7.0 (8.1)

38

FRAX-BMD for MOF (SD)

4.9 (2.6)

75,273

8.1 (4.4)

2

11.1 (6.3)

19

17.1 (9.5)

151

FRAX-BMD for hip fracture (SD)

0.7 (1.0)

75,273

2.5 (3.3)

2

5.3 (5.5)

19

5.0 (6.7)

151

Incident major osteoporotic fracture (incidence proportion)

1189 (1.5)

560 (12.0)

337 (17.9)

707 (20.6)

323 (1.3)

Incident hip fracture (incidence proportion)

209 (0.3)

273 (5.9)

129 (6.9)

556 (15.6)

67 (0.3)