Table 1 Study characteristics
From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score
| Characteristic | UK Biobank test dataset | MrOS US | MrOS Sweden | SOF | CKB | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Mean/N | Missing/N | Mean/N | Missing/N | Mean/N | Missing/N | Mean/N | Missing/N | Mean/N | Missing/N | |
| Sample size | 80,014 | 4663 | 1880 | 3615 | 25,034 | |||||
| Baseline age (SD) | 56.8 (8.0) | 74.0 (6.0) | 75.4 (3.2) | 71.5 (5.3) | 53.7 (11.0) | |||||
| Women (%) | 43,723 (54.6) | 0 | 0 | 3615 (100) | 14,334 (57.3) | |||||
| Baseline BMI (SD) | 27.3 (4.7) | 4 | 27.4 (3.8) | 1 | 26.4 (3.5) | 26.7 (4.6) | 23.7 (3.5) | |||
| Prior fracture (%) | 8008 (10.0) | 21 | 1087 (23.3) | 4 | 637 (33.9) | 1 | 1274 (35.4) | 17 | 2290 (9.2) | |
| Smoking (%) | 6908 (8.6) | 146 (3.1) | 1 | 178 (9.5) | 6 | 285 (7.9) | 13 | 7957 (31.8) | ||
| Corticosteroids use (%) | 923 (1.2) | 98 (2.2) | 164 | 34 (1.8) | 6 | 387 (10.9) | 62 | 25,034 | ||
| Rheumatoid arthritis (%) | 758 (1.0) | 226 (4.8) | 27 (1.5) | 23 | 252 (7.1) | 74 | 572 (2.3) | |||
| Parental fracture (%) | 80,014 | 600 (16.8) | 1098 | 164 (13.7) | 686 | 424 (14.3) | 646 | 25,034 | ||
| At-risk drinking* (%) | 80,014 | 182 (3.9) | 6 | 52 (2.8) | 27 | 102 (2.8) | 1 | 25,034 | ||
| Baseline falls§ (%) | 80,014 | 984 (21.1) | 298 (15.9) | 6 | 1021 (28.3) | 6 | 25,034 | |||
| Secondary osteoporosis (%) | 3352 (4.2) | 4663 | 1880 | 3615 | 25,034 | |||||
| FRAX for MOF (SD) | 5.1 (3.1) | 9.5 (4.7) | 1 | 13.1 (5.6) | 18.7 (9.5) | |||||
| FRAX for hip fracture (SD) | 0.7 (0.9) | 3.8 (3.8) | 1 | 7.0 (4.9) | 6.4 (7.0) | |||||
| FRAX-gSOS for MOF (SD) | 5.4 (3.9) | 10.1 (6.0) | 6 | 13.7 (7.3) | 19.3 (11.2) | 38 | ||||
| FRAX-gSOS for hip fracture (SD) | 0.9 (1.2) | 4.2 (4.8) | 6 | 7.7 (6.5) | 7.0 (8.1) | 38 | ||||
| FRAX-BMD for MOF (SD) | 4.9 (2.6) | 75,273 | 8.1 (4.4) | 2 | 11.1 (6.3) | 19 | 17.1 (9.5) | 151 | ||
| FRAX-BMD for hip fracture (SD) | 0.7 (1.0) | 75,273 | 2.5 (3.3) | 2 | 5.3 (5.5) | 19 | 5.0 (6.7) | 151 | ||
| Incident major osteoporotic fracture (incidence proportion) | 1189 (1.5) | 560 (12.0) | 337 (17.9) | 707 (20.6) | 323 (1.3) | |||||
| Incident hip fracture (incidence proportion) | 209 (0.3) | 273 (5.9) | 129 (6.9) | 556 (15.6) | 67 (0.3) | |||||