Table 3 Net reclassification improvement of fracture risk prediction using FRAX-gSOS
From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score
Cohort | UKB* | US§ | SWE¶ | SOF†| UKB | US | SWE | SOF |
|---|---|---|---|---|---|---|---|---|
Major osteoporotic fracture | Hip fracture | |||||||
\Categorical NRI (95% CI) | 0.028 (0.016–0.039) | 0.043 (0.020–0.066) | 0.072 (0.027–0.118) | 0.024 (− 0.008–0.056) | 0.055 (0.009–0.100) | 0.066 (0.025–0.107) | 0.037 (− 0.012–0.085) | − 0.001 (− 0.034–0.031) |
Continuous NRI (95% CI) | 0.300 (0.245–0.354) | 0.179 (0.092–0.267) | 0.232 (0.116–0.348) | 0.237 (0.155–0.318) | 0.206 (0.073–0.339) | 0.180 (0.060–0.300) | 0.132 (− 0.045–0.310) | 0.205 (0.116–0.295) |
IDI (95% CI) | 0.010 (0.008–0.011) | 0.011 (0.008–0.015) | 0.014 (0.009–0.019) | 0.017 (0.012–0.021) | 0.003 (0.001–0.005) | 0.007 (0.003–0.011) | 0.004 (− 0.002–0.011) | 0.011 (0.007–0.015) |