Skip to main content

Table 3 Net reclassification improvement of fracture risk prediction using FRAX-gSOS

From: Improved prediction of fracture risk leveraging a genome-wide polygenic risk score

Cohort UKB* US§ SWE SOF UKB US SWE SOF
Major osteoporotic fracture Hip fracture
\Categorical NRI (95% CI) 0.028 (0.016–0.039) 0.043 (0.020–0.066) 0.072 (0.027–0.118) 0.024 (− 0.008–0.056) 0.055 (0.009–0.100) 0.066 (0.025–0.107) 0.037 (− 0.012–0.085) − 0.001 (− 0.034–0.031)
Continuous NRI (95% CI) 0.300 (0.245–0.354) 0.179 (0.092–0.267) 0.232 (0.116–0.348) 0.237 (0.155–0.318) 0.206 (0.073–0.339) 0.180 (0.060–0.300) 0.132 (− 0.045–0.310) 0.205 (0.116–0.295)
IDI (95% CI) 0.010 (0.008–0.011) 0.011 (0.008–0.015) 0.014 (0.009–0.019) 0.017 (0.012–0.021) 0.003 (0.001–0.005) 0.007 (0.003–0.011) 0.004 (− 0.002–0.011) 0.011 (0.007–0.015)
  1. *The UK Biobank test dataset (N = 80,014)
  2. §The MrOS US cohort (N = 4663)
  3. The MrOS Sweden cohort (N = 1880)
  4. The SOF cohort (N = 3615)