TY - JOUR AU - Shafighi, Shadi Darvish AU - Kiełbasa, Szymon M. AU - Sepúlveda-Yáñez, Julieta AU - Monajemi, Ramin AU - Cats, Davy AU - Mei, Hailiang AU - Menafra, Roberta AU - Kloet, Susan AU - Veelken, Hendrik AU - van Bergen, Cornelis A.M. AU - Szczurek, Ewa PY - 2021 DA - 2021/03/24 TI - CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells JO - Genome Medicine SP - 45 VL - 13 IS - 1 AB - Drawing genotype-to-phenotype maps in tumors is of paramount importance for understanding tumor heterogeneity. Assignment of single cells to their tumor clones of origin can be approached by matching the genotypes of the clones to the mutations found in RNA sequencing of the cells. The confidence of the cell-to-clone mapping can be increased by accounting for additional measurements. Follicular lymphoma, a malignancy of mature B cells that continuously acquire mutations in parallel in the exome and in B cell receptor loci, presents a unique opportunity to join exome-derived mutations with B cell receptor sequences as independent sources of evidence for clonal evolution. SN - 1756-994X UR - https://doi.org/10.1186/s13073-021-00842-w DO - 10.1186/s13073-021-00842-w ID - Shafighi2021 ER -