Fig. 4

Validation of cell-to-clone assignment with gene expression for subject S12118. Figure panels as for subject S144 in Fig. 3. Also for subject S12118, assignment to clones for cells in multiplet BCR clusters using CACTUS (a) improves agreement with gene expression data compared to assignment of cells in singleton BCR clusters (d) and assignment using cardelino [21] (b), as quantified using connectivity measure (c). For singleton BCR clusters, CACTUS performs comparably well as cardelino