Fig. 6

BCR cluster assignment to tumor clones, for both subjects. S144 (a, b) and S12118 (c, d), using CACTUS (a, c) and cardelino [21] (b, d). Heatmaps with shades of green indicate the proportion of cells in multiplet cluster (y axis) assigned to clones (x axis). Each number in a green entry indicates the non-zero number of cells of the corresponding BCR clusters assigned to the corresponding clone. Only BCR clusters of at least two cells are featured. As expected, for both subjects, CACTUS assigns entire BCR clusters to single clones (a, c). For cardelino, the proportions of BCR clusters are more distributed across the clones (b, d)