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Table 1 Quantification of the agreement of the cell-to-clone assignment with gene expression profiles of the cells

From: CACTUS: integrating clonal architecture with genomic clustering and transcriptome profiling of single tumor cells

Subject Type Method Dunn index RMSSTD CH Connectivity
S144 Multiplet CACTUS 0.066 57.0 15.6 898.9
   cardelino 0.057 77.1 3.2 1250.9
  Singleton CACTUS 0.054 110.9 3.2 839.5
   cardelino 0.052 109.5 1.9 711.9
S12118 Multiplet CACTUS 0.098 79.2 11.9 169.6
   cardelino 0.084 96.2 10.0 495.0
  Singleton CACTUS 0.085 105.4 4.1 285.4
   cardelino 0.092 99.4 3.9 396.5
  1. Bolded values indicate which method (CACTUS or cardelino) obtained better agreement for the given subject and type of cluster that the cells assigned to the clones come from. High values of the Dunn index and the Calinski-Harabasz (CH) index, as well as low values of the root mean square standard deviation (RMSSTD) and connectivity quantify to what extent the gene expression of the cells is homogeneous inside each clone and differs between the clones