TY - JOUR AU - Wang, Yanqun AU - Wang, Daxi AU - Zhang, Lu AU - Sun, Wanying AU - Zhang, Zhaoyong AU - Chen, Weijun AU - Zhu, Airu AU - Huang, Yongbo AU - Xiao, Fei AU - Yao, Jinxiu AU - Gan, Mian AU - Li, Fang AU - Luo, Ling AU - Huang, Xiaofang AU - Zhang, Yanjun AU - Wong, Sook-san AU - Cheng, Xinyi AU - Ji, Jingkai AU - Ou, Zhihua AU - Xiao, Minfeng AU - Li, Min AU - Li, Jiandong AU - Ren, Peidi AU - Deng, Ziqing AU - Zhong, Huanzi AU - Xu, Xun AU - Song, Tie AU - Mok, Chris Ka Pun AU - Peiris, Malik AU - Zhong, Nanshan AU - Zhao, Jingxian AU - Li, Yimin AU - Li, Junhua AU - Zhao, Jincun PY - 2021 DA - 2021/02/22 TI - Intra-host variation and evolutionary dynamics of SARS-CoV-2 populations in COVID-19 patients JO - Genome Medicine SP - 30 VL - 13 IS - 1 AB - Since early February 2021, the causative agent of COVID-19, SARS-CoV-2, has infected over 104 million people with more than 2 million deaths according to official reports. The key to understanding the biology and virus-host interactions of SARS-CoV-2 requires the knowledge of mutation and evolution of this virus at both inter- and intra-host levels. However, despite quite a few polymorphic sites identified among SARS-CoV-2 populations, intra-host variant spectra and their evolutionary dynamics remain mostly unknown. SN - 1756-994X UR - https://doi.org/10.1186/s13073-021-00847-5 DO - 10.1186/s13073-021-00847-5 ID - Wang2021 ER -