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Fig. 3 | Genome Medicine

Fig. 3

From: Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression

Fig. 3

Association plot summarising all nominally significant association between MacTel SNPs and the endophenotypes (Additional File 6: Table S5). SNPs are divided into categories based on MR results. Each dot represents the nominal p-value for each association between all SNPs and endophenotypes. Red dots indicate that MacTel risk alleles for that SNP also increases the risk of the retinal phenotype, while blue dots indicate a reduced risk. The dashed line represents the nominal significance of p = 0.05. The top right corner displays the ETDRS grid for the right eye (OD) [31] used to divide the endophenotypes into 9 retinal areas: 1: foveal area, 2: superior inner area, 3: nasal inner area, 4: inferior inner area, 5: temporal inner area, 6: superior outer area, 7: nasal outer area, 8: inferior outer area and 9: temporal outer area. Although definitions vary across the literature, for simplicity, in this manuscript, we define the pink area as the “MacTel [onset] area” while the green areas are MacTel “progression areas”

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