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Table 1 Significant associations between mPRS and tPRS and MacTel. Regression coefficients are presented in the “Beta” column. Odds ratios (OR) are relative to a single standard deviation increase on the mPRS/tPRS scale. Odds ratios 95% confidence intervals are shown in the “95% C.I.” column. Benjamini-Hochberg-adjusted p values are presented under the “p value” column

From: Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression

Metabolite/Trait PRS Beta OR 95% C.I. p value Biochemical Family
Serine −0.65 0.52 0.46–0.58 8.38E−28 Amino acids and biogenic amines
Glycine −0.58 0.56 0.50–0.63 5.44E−19 Amino acids and biogenic amines
Lysophosphatidylcholine acyl C14:0 0.21 1.23 1.11–1.37 2.48E−03 Glycerophospholipids
Phosphatidylcholine diacyl C32:1 0.21 1.23 1.11–1.37 2.48E−03 Glycerophospholipids
Phosphatidylcholine diacyl C34:1 0.21 1.23 1.11–1.37 2.48E−03 Glycerophospholipids
Phosphatidylcholine with acyl-alkyl residue C38:1 0.20 1.22 1.10–1.36 2.97E−03 Glycerophospholipids
Arginine 0.17 1.18 1.07–1.31 2.83E−02 Amino acids and biogenic amines
Phenylalanine −0.17 0.85 0.76–0.94 2.85E−02 Amino acids and biogenic amines
Arteriolar retinal calibre 0.32 1.38 1.25–1.52 2.22E−10 Vasculature trait
Venular retinal calibre 0.18 1.19 1.08–1.32 7.00E−04 Vasculature trait
T2D 0.17 1.19 1.07–1.33 7.72E−04 Comorbidity