Table 1 Significant associations between mPRS and tPRS and MacTel. Regression coefficients are presented in the “Beta” column. Odds ratios (OR) are relative to a single standard deviation increase on the mPRS/tPRS scale. Odds ratios 95% confidence intervals are shown in the “95% C.I.” column. Benjamini-Hochberg-adjusted p values are presented under the “p value” column
Metabolite/Trait PRS | Beta | OR | 95% C.I. | p value | Biochemical Family |
|---|---|---|---|---|---|
Serine | −0.65 | 0.52 | 0.46–0.58 | 8.38E−28 | Amino acids and biogenic amines |
Glycine | −0.58 | 0.56 | 0.50–0.63 | 5.44E−19 | Amino acids and biogenic amines |
Lysophosphatidylcholine acyl C14:0 | 0.21 | 1.23 | 1.11–1.37 | 2.48E−03 | Glycerophospholipids |
Phosphatidylcholine diacyl C32:1 | 0.21 | 1.23 | 1.11–1.37 | 2.48E−03 | Glycerophospholipids |
Phosphatidylcholine diacyl C34:1 | 0.21 | 1.23 | 1.11–1.37 | 2.48E−03 | Glycerophospholipids |
Phosphatidylcholine with acyl-alkyl residue C38:1 | 0.20 | 1.22 | 1.10–1.36 | 2.97E−03 | Glycerophospholipids |
Arginine | 0.17 | 1.18 | 1.07–1.31 | 2.83E−02 | Amino acids and biogenic amines |
Phenylalanine | −0.17 | 0.85 | 0.76–0.94 | 2.85E−02 | Amino acids and biogenic amines |
Arteriolar retinal calibre | 0.32 | 1.38 | 1.25–1.52 | 2.22E−10 | Vasculature trait |
Venular retinal calibre | 0.18 | 1.19 | 1.08–1.32 | 7.00E−04 | Vasculature trait |
T2D | 0.17 | 1.19 | 1.07–1.33 | 7.72E−04 | Comorbidity |