Fig. 2

Two-sample Mendelian randomization estimates for the association between genetically predicted systolic blood pressure per 10-mmHg and atrial fibrillation as the main outcome, and coronary heart disease, myocardial infarction, and ischemic stroke as positive control outcomes. Solid squares represent point estimates and vertical lines 95% confidence intervals (CI). Cases and controls: number of cases and controls in genome-wide association studies. Odds ratio estimated using the inverse-variance weighted method