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Table 3 Differentially abundant OTUs between NG and PD subjects (Indian cohort)

From: Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

OTU IDs

Taxonomic affiliation

Log2 fold change

Log2 FC standard error

BH-adjusted p value (padj)

Mean % abundance

Log2 FC in Denmark (and padj value)

Enriched in NG (India)

 526358 *

Faecalibacterium

− 1.4023

0.3430

2.00E−03

0.0272

0.2549 (0.7247)

 363017 *

Ruminococcaceae_UCG-002

− 1.2560

0.2843

5.70E−04

0.0254

− 0.5792 (0.1898)

 211935 *

Agathobacter

− 1.4328

0.4420

2.65E−02

0.0142

− 0.4730 (0.6316)

 583256 *

Faecalibacterium

− 2.8392

0.3956

1.27E−10

0.0126

− 0.4154 (0.6150)

 321743 *

Prevotella_9

− 1.5612

0.4585

1.75E−02

0.0097

− 0.8695 (NA)

 177679

[Family]Muribaculaceae

− 1.8582

0.5292

1.35E−02

0.0062

− 1.1579 (0.5283)

 3910247 *

Alloprevotella

− 2.7503

0.7581

9.27E−03

0.0056

0.5692 (NA)

 4295618

Prevotella_9

− 1.6808

0.5665

4.82E−02

0.0054

0.0614 (NA)

 denovo143775

Prevotella_9

− 4.3633

1.1914

8.48E−03

0.0037

NA

 denovo94756

Prevotella_9

− 3.6581

1.1732

3.53E−02

0.0028

NA

Enriched in PD (India)

 1121530 *

Lactobacillus ruminis

1.6953

0.2990

1.56E−06

2.8598

− 0.5500 (0.7993)

 264967 *

Megasphaera

2.7006

0.4177

1.54E−08

0.6834

0.1234 (NA)

 361811 *

Subdoligranulum

1.6443

0.2547

1.54E−08

0.5463

0.2621 (0.6316)

 1111294 *

Escherichia/Shigella albertii/boydii/coli/dysenteriae/fergusonii/flexneri/sonnei/vulneris

3.0148

0.3638

4.12E−14

0.5294

− 0.1181 (0.9126)

 661,229 *

GKS98_freshwater_group

1.9029

0.5708

2.04E−02

0.4334

− 0.5283 (NA)

 333178 *

Lactobacillus ruminis

1.4600

0.3529

1.73E−03

0.3985

− 1.2126 (0.6758)

 1105343 *

Ruminococcaceae_UCG-013

1.2424

0.3720

2.02E−02

0.3401

0.7922 (0.0164)

 583746 *

Dialister succinatiphilus

1.3217

0.4431

4.71E−02

0.3357

− 1.9138 (0.3338)

 1767788

Vibrio cholerae

4.6414

0.8994

2.20E−05

0.3053

2.1842 (0.1198)

 denovo49732 *

Lactobacillus

2.2333

0.3784

4.27E−07

0.2630

− 0.7778 (0.7655)

 292057

Lactobacillus phage/reuteri/salivarius

1.8088

0.5630

2.80E−02

0.2333

1.0336 (NA)

 813217 *

Klebsiella aerogenes/oxytoca/pneumoniae

1.2564

0.3633

1.50E−02

0.1797

0.5921 (0.7735)

 355307 *

Subdoligranulum

1.4338

0.2712

1.27E−05

0.1645

0.4640 (0.3236)

 558264 *

Achromobacter insolitus/xylosoxidans

1.6829

0.4317

3.73E−03

0.1429

0.1816 (NA)

 328283 *

Streptococcus

1.9115

0.4641

1.81E−03

0.1397

0.6262 (NA)

  1. Differentially abundant OTUs between NG and PD subjects, belonging to the Indian cohort, identified using a negative binomial Wald test. A positive log2 fold change value indicates higher relative abundance of the OTU in PD subjects and vice versa. P values were adjusted for multiple testing using Benjamini-Hochberg correction. Up to top 15 OTUs (sorted according to mean abundance values) which are at least twofold enriched (padj < 0.05) either in the NG or the PD group are listed. The rightmost column depicts the log2 fold change (if any) for the same OTU in the Danish cohort with the respective padj values in brackets. “NA” in the rightmost column indicates absence (or limited abundance and/or ubiquity) of the OTU in the Danish cohort. OTUs marked with an asterisk (*) were also found to exhibit significant differential abundance between NG and PD groups in the Indian cohort after correcting for following factors—age, gender, waist-to-hip ratio, systolic BP, IL6, TNFα, LBP, and IAP. Further details in Additional file 13 Tables S8A and S8B
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Genome Medicine

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