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Table 4 Differentially abundant OTUs between NG and PD subjects (Danish cohort)

From: Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

OTU IDs

Taxonomic affiliation

Log2 fold change

Log2 FC standard error

BH-adjusted p value (padj)

Mean % abundance

Log2 FC in India (and padj value)

Enriched in NG (Denmark)

 530653

Prevotella_9

− 2.1696

0.6476

2.72E−02

0.5973

0.8215 (0.1061)

 556835

Phascolarctobacterium faecium

− 2.5626

0.5608

6.30E−04

0.5759

0.4750 (0.8399)

 840914

Prevotella_9

− 3.0817

0.7375

2.77E−03

0.2892

0.9944 (0.2645)

 569244 *

[Order]Mollicutes_RF39

− 2.2544

0.5219

1.84E−03

0.0900

0.7955 (0.4533)

 366352

Ruminococcus_1

− 1.3403

0.3808

1.75E−02

0.0898

− 0.3344 (0.8399)

 300855

Family_XIII_AD3011_group

− 1.0533

0.3375

4.91E−02

0.0185

0.0672 (0.9621)

 denovo21348

Prevotella_9

− 3.3626

1.0755

4.91E−02

0.0093

0.1213 (NA)

 denovo64437

Oscillibacter

− 1.6014

0.4896

3.37E−02

0.0092

1.2417 (0.1523)

 denovo154693

Ruminococcaceae_UCG-005

− 2.0648

0.5084

3.84E−03

0.0067

0.3536 (NA)

 190220

Ruminococcaceae_UCG-002

− 1.7534

0.5639

4.91E−02

0.0039

2.5112 (0.0841)

 denovo56680 *

Ruminococcaceae_NK4A214_group

− 2.0885

0.6214

2.69E−02

0.0034

0.2107 (NA)

Enriched in PD (Denmark)

 535375

Bacteroides fragilis/ovatus

1.2882

0.3102

2.91E−03

0.4990

0.0167 (0.9890)

 212481 *

Lachnoclostridium

1.4087

0.2772

8.84E−05

0.4144

0.5648 (0.2787)

 269937

Prevotella_2

4.5234

1.2712

1.64E−02

0.2741

− 0.9062 (0.4702)

 187623 *

Bacteroides fragilis/xylanisolvens

1.1188

0.3283

2.44E−02

0.2018

0.4457 (0.6316)

 212359

Lachnospiraceae_NK4A136_group

1.0452

0.3360

4.91E−02

0.1308

− 0.4899 (0.4494)

 332732

Bacteroides intestinalis

3.1027

0.5724

1.68E−05

0.1138

1.9399 (0.2202)

 370361

[Family]Lachnospiraceae

2.1163

0.4551

4.71E−04

0.1056

1.3856 (0.1324)

 361108 *

Lachnoclostridium

5.2401

0.8119

7.70E−08

0.0944

1.5206 (0.3246)

 302,538

Prevotella_2

4.8436

1.3556

1.64E−02

0.0728

− 0.1564 (0.9519)

 297045

Ruminiclostridium_9

2.1947

0.3231

1.55E−08

0.0578

0.0173 (0.9894)

 326662

Bacteroides

4.2505

1.3187

3.82E−02

0.0475

− 0.5035 (0.8716)

 564806

Lachnoclostridium

1.8245

0.5267

2.04E−02

0.0408

− 0.0955 (0.9760)

 4449055

Bacteroides

3.4554

0.9515

1.48E−02

0.0405

0.9578 (0.5667)

 549635

Blautia

2.8875

0.8503

2.48E−02

0.0363

− 1.7466 (0.4146)

 422283

Ruminiclostridium_9

1.3861

0.3352

2.96E−03

0.0307

− 0.3696 (0.8889

  1. Differentially abundant OTUs between NG and PD subjects, belonging to the Danish cohort, identified using a negative binomial Wald test. A positive log2 fold change value indicates higher relative abundance of the OTU in PD subjects and vice versa. P values were adjusted for multiple testing using Benjamini-Hochberg correction. Up to top 15 OTUs (sorted according to mean abundance values) which are at least twofold enriched (padj < 0.05) either in the NG or the PD group are listed. The rightmost column depicts the log2 fold change (if any) for the same OTU in the Indian cohort with the respective padj values in brackets. “NA” in the rightmost column indicates absence (or limited abundance and/or ubiquity) of the OTU in the Indian cohort. OTUs marked with an asterisk (*) were also found to exhibit significant differential abundance between NG and PD groups in the Danish cohort after correcting for following factors—age, gender, waist-to-hip ratio, systolic BP, IL6, TNFα, LBP, and IAP. Further details in Additional file 14 Tables S9A and S9B
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Genome Medicine

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