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Table 4 Differentially abundant OTUs between NG and PD subjects (Danish cohort)

From: Trans-ethnic gut microbial signatures of prediabetic subjects from India and Denmark

OTU IDs Taxonomic affiliation Log2 fold change Log2 FC standard error BH-adjusted p value (padj) Mean % abundance Log2 FC in India (and padj value)
Enriched in NG (Denmark)
 530653 Prevotella_9 − 2.1696 0.6476 2.72E−02 0.5973 0.8215 (0.1061)
 556835 Phascolarctobacterium faecium − 2.5626 0.5608 6.30E−04 0.5759 0.4750 (0.8399)
 840914 Prevotella_9 − 3.0817 0.7375 2.77E−03 0.2892 0.9944 (0.2645)
 569244 * [Order]Mollicutes_RF39 − 2.2544 0.5219 1.84E−03 0.0900 0.7955 (0.4533)
 366352 Ruminococcus_1 − 1.3403 0.3808 1.75E−02 0.0898 − 0.3344 (0.8399)
 300855 Family_XIII_AD3011_group − 1.0533 0.3375 4.91E−02 0.0185 0.0672 (0.9621)
 denovo21348 Prevotella_9 − 3.3626 1.0755 4.91E−02 0.0093 0.1213 (NA)
 denovo64437 Oscillibacter − 1.6014 0.4896 3.37E−02 0.0092 1.2417 (0.1523)
 denovo154693 Ruminococcaceae_UCG-005 − 2.0648 0.5084 3.84E−03 0.0067 0.3536 (NA)
 190220 Ruminococcaceae_UCG-002 − 1.7534 0.5639 4.91E−02 0.0039 2.5112 (0.0841)
 denovo56680 * Ruminococcaceae_NK4A214_group − 2.0885 0.6214 2.69E−02 0.0034 0.2107 (NA)
Enriched in PD (Denmark)
 535375 Bacteroides fragilis/ovatus 1.2882 0.3102 2.91E−03 0.4990 0.0167 (0.9890)
 212481 * Lachnoclostridium 1.4087 0.2772 8.84E−05 0.4144 0.5648 (0.2787)
 269937 Prevotella_2 4.5234 1.2712 1.64E−02 0.2741 − 0.9062 (0.4702)
 187623 * Bacteroides fragilis/xylanisolvens 1.1188 0.3283 2.44E−02 0.2018 0.4457 (0.6316)
 212359 Lachnospiraceae_NK4A136_group 1.0452 0.3360 4.91E−02 0.1308 − 0.4899 (0.4494)
 332732 Bacteroides intestinalis 3.1027 0.5724 1.68E−05 0.1138 1.9399 (0.2202)
 370361 [Family]Lachnospiraceae 2.1163 0.4551 4.71E−04 0.1056 1.3856 (0.1324)
 361108 * Lachnoclostridium 5.2401 0.8119 7.70E−08 0.0944 1.5206 (0.3246)
 302,538 Prevotella_2 4.8436 1.3556 1.64E−02 0.0728 − 0.1564 (0.9519)
 297045 Ruminiclostridium_9 2.1947 0.3231 1.55E−08 0.0578 0.0173 (0.9894)
 326662 Bacteroides 4.2505 1.3187 3.82E−02 0.0475 − 0.5035 (0.8716)
 564806 Lachnoclostridium 1.8245 0.5267 2.04E−02 0.0408 − 0.0955 (0.9760)
 4449055 Bacteroides 3.4554 0.9515 1.48E−02 0.0405 0.9578 (0.5667)
 549635 Blautia 2.8875 0.8503 2.48E−02 0.0363 − 1.7466 (0.4146)
 422283 Ruminiclostridium_9 1.3861 0.3352 2.96E−03 0.0307 − 0.3696 (0.8889
  1. Differentially abundant OTUs between NG and PD subjects, belonging to the Danish cohort, identified using a negative binomial Wald test. A positive log2 fold change value indicates higher relative abundance of the OTU in PD subjects and vice versa. P values were adjusted for multiple testing using Benjamini-Hochberg correction. Up to top 15 OTUs (sorted according to mean abundance values) which are at least twofold enriched (padj < 0.05) either in the NG or the PD group are listed. The rightmost column depicts the log2 fold change (if any) for the same OTU in the Indian cohort with the respective padj values in brackets. “NA” in the rightmost column indicates absence (or limited abundance and/or ubiquity) of the OTU in the Indian cohort. OTUs marked with an asterisk (*) were also found to exhibit significant differential abundance between NG and PD groups in the Danish cohort after correcting for following factors—age, gender, waist-to-hip ratio, systolic BP, IL6, TNFα, LBP, and IAP. Further details in Additional file 14 Tables S9A and S9B