Table 1 Hypermutated samples with TMB > 10 and potential somatic variants known to be associated with hypermutation
From: Clinical-grade whole-genome sequencing and 3′ transcriptome analysis of colorectal cancer patients
Sample | TMB (Muts/mb) | Potential somatic variants |
|---|---|---|
A03 | 206.25 | POLD1 (p.Leu227Pro) |
A09 | 85.47 | PMS1 (p.Ser118Ter) |
A10 | 95.41 | MSH3 (p.Val393Ala) |
A12 | 143.31 | None detected |
B05 | 221.68 | MSH3 (p.Lys383ArgfsTer32) MLH3 (p.Lys383ArgfsTer32) POLE (p.Arg759Cys) |
B08 | 577.91 | POLE (p.Pro286Arg) |