TY - JOUR AU - Alvarez-Silva, Camila AU - Kashani, Alireza AU - Hansen, Tue Haldor AU - Pinna, Nishal Kumar AU - Anjana, Ranjit Mohan AU - Dutta, Anirban AU - Saxena, Shruti AU - Støy, Julie AU - Kampmann, Ulla AU - Nielsen, Trine AU - Jørgensen, Torben AU - Gnanaprakash, Visvanathan AU - Gnanavadivel, Rameshkumar AU - Sukumaran, Aswath AU - Rani, Coimbatore Subramanian Shanthi AU - Færch, Kristine AU - Radha, Venkatesan AU - Balasubramanyam, Muthuswamy AU - Nair, Gopinath Balakrish AU - Das, Bhabatosh AU - Vestergaard, Henrik AU - Hansen, Torben AU - Mande, Sharmila Shekhar AU - Mohan, Viswanathan AU - Arumugam, Manimozhiyan AU - Pedersen, Oluf PY - 2021 DA - 2021/03/03 TI - Trans-ethnic gut microbiota signatures of type 2 diabetes in Denmark and India JO - Genome Medicine SP - 37 VL - 13 IS - 1 AB - Type 2 diabetes (T2D), a multifactorial disease influenced by host genetics and environmental factors, is the most common endocrine disease. Several studies have shown that the gut microbiota as a close-up environmental mediator influences host physiology including metabolism. The aim of the present study is to examine the compositional and functional potential of the gut microbiota across individuals from Denmark and South India with a focus on T2D. Many earlier studies have investigated the microbiome aspects of T2D, and it has also been anticipated that such microbial associations would be dependent on diet and ethnic origin. However, there has been no large scale trans-ethnic microbiome study earlier in this direction aimed at evaluating any “universal” microbiome signature of T2D. SN - 1756-994X UR - https://doi.org/10.1186/s13073-021-00856-4 DO - 10.1186/s13073-021-00856-4 ID - Alvarez-Silva2021 ER -