Fig. 4

Number and distribution of mutations in driver genes as captured by whole-exome sequencing. a Number of shared (light gray) and private (dark gray) mutations in driver genes. *p < 0.01. b Number of private mutations in driver genes, in the primary tumor (light gray), or in metastases (dark gray). *p < 0.01. c Fraction of overall or driver mutations detected in both primary tumors and metastases. *p<0.01 Lines correspond to the mean