Fig. 2
From: Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
Microglial PGC-1α protects against ischemia-induced brain damage in mice. a The schematic of experimental protocols. b The percent survival of PGC-1αf/f and mPGC-1α mice after tMCAO. n = 16 per group. The mNSS score (c), corner-turning test (d), foot-fault test (e), and time on rotarod (f) were used to evaluate the neurological functions of motor, sensory, and balance between the PGC-1αf/f and mPGC-1α mice. n = 10 per group. g Infarct size was defined by TTC staining (left panel) and quantified using Image-Pro-Plus 6.0 software (right panel). n = 7 per group. h Analysis of neuronal apoptosis in the PGC-1αf/f and mPGC-1α mice using TUNEL staining (left panel). Quantification of TUNEL/NeuN double-positive cells using ImageJ software (right panel). *p < 0.05, **p < 0.01; n = 6 per group