Fig. 5
From: Microglial PGC-1α protects against ischemic brain injury by suppressing neuroinflammation
Identification of genome-wide transcriptional targets of PGC-1α. a Density distribution of PGC-1α ChIP-Seq peaks. b Heat maps of PGC-1α ChIP-Seq and input signals. c The intersections between two samples were calculated. Left: A scatterplot visualizing the relationship between the two samples. Right: A Venn diagram displaying the number of overlapping and nonoverlapping peaks between the two samples. d Genomic distribution of the transcriptional targets of PGC-1α. e De novo motif enrichments identified using HOMER at the overlapping peaks. The top three identified motifs are shown. f GO analysis showed the top 10 enriched biological processes. g KEGG pathway analysis for the genes that had PGC-1α-binding peaks in their promoter regions (− 2 to 2 kb around TSS)