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Fig. 2 | Genome Medicine

Fig. 2

From: Finding associations in a heterogeneous setting: statistical test for aberration enrichment

Fig. 2

Examples of considered scenarios for aberration enrichment pattern. r controls the proportion of individuals affected among the cases and d is the magnitude of the effect within those individuals. a r=0.05, d=3, n=500b r=0.15, d=1.5, n=500. Note that the aberration enrichment pattern often appears as a heavier tail for cases rather than a secondary cluster of cases especially for lower values of r. Intuitively, d affects the location of the red area relative to the mean of the distribution while r more specifically affects the size of the red area

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