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Fig. 7 | Genome Medicine

Fig. 7

From: PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling

Fig. 7

Upregulation of SMARCA4 positively correlates with expression of EGFR and TNS4 and is associated with poor prognosis of CRC patients. a Hematoxylin and eosin (H&E) staining and IHC staining of SMARCA4 protein in adjacent normal colon tissue controls (NAT) and colorectal cancer (CRC) in human tissues. Representative micrographs are shown in original magnification (× 200) as indicated (left); total IHC score of SMARCA4 in NAT and CRC tissues (n = 90); **P < 0.01 (right). Scale bar, 50 μm. b Correlation of SMARCA4 expression and tumor size in CRC patients; *P < 0.05. c Kaplan–Meier plot of overall survival of 90 patients with colorectal cancer, stratified by SMARCA4 expression; log-rank test, P < 0.0001. d Pearson correlation scatter plot of H scores of PRMT1 or SMARCA4, and TNS4 or EGFR in human colorectal cancer (n = 90)

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Genome Medicine

ISSN: 1756-994X

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